It has been discussed here before, but look up the Philadelphia incident with Bill Burr. The backstory is that he was performing at an outdoor comedy festival and was following Dom Irrera, a comedian's comedian and one of the favorites of many active comedians because he has mentored and paved the way for so many others. The Philly crowd had just booed Dom. He was pretty pissed about it. Kind of like if someone had heckled your frail grandfather. So Burr goes out and starts his set, pretty pissed from the outset. The crowd begins to heckle him, so he discards his planned 15 minute set and goes on a tirade against everything Philadelphia for a full 12-13 minutes. It is not for the faint of heart. He made himself a legend within the comedy world with this performance.
** He had to finish his 15 minute set in order to be paid.