We can debate whether Mayfield's actions were a reaction to KUs failure to shake hands. I suspect that he was already mouthing off prior to the handshake.
Never the less it's hard to get 18 and 19 year olds not to respond in kind. I hope this is not who we are. Don't know how many coaches or players look at this site.
I would suggest we shake his hand, never say a word. Lay him on his ass as often as possible but legally, frustrate him by covering his receivers and keeping him on the run. If the Sooner players are playing dirty, kicking, hitting, spitting, let the coaches know. otherwise don't respond in kind. After we beat him, shake his hand and take the high road. Let him be who he is going to be.